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Poster Session A: Tuesday, August 12, 1:30 – 4:30 pm, de Brug & E‑Hall

Neuroinflammatory Cascades in Urethritis-Mediated Cognitive Dysfunction: Computational Frameworks and Multiscale Modeling Perspectives

Saket Ram Ganti¹; ¹San Joaquin Delta College

Presenter: Saket Ram Ganti

Emerging research reveals a compelling and underrecognized connection between urological inflammation and cognitive dysfunction, particularly in the context of urethritis. Traditionally viewed as a localized condition affecting the lower urinary tract, urethritis is now gaining attention for its potential to trigger systemic effects, including neuroinflammatory responses that disrupt brain function. This paper investigates the hypothesis that urethritis-induced inflammation may contribute to cognitive impairment through a cascade of immunological, biochemical, and neural interactions. We explore how peripheral immune activation can influence central nervous system (CNS) homeostasis, leading to alterations in neural circuitry and behavior. By integrating insights from neuroimmunology, computational neuroscience, and systems-level modeling, we propose a multidimensional framework for understanding how peripheral pathology can manifest as central dysfunction. This interdisciplinary approach not only bridges the gap between urology and neuroscience but also shows new avenues for early diagnosis, predictive modeling, and targeted interventions for inflammation-associated cognitive decline.

Topic Area: Methods & Computational Tools

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