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Poster Session A: Tuesday, August 12, 1:30 – 4:30 pm, de Brug & E‑Hall

Distinct Value & Choice Information Across Putative Subtypes of Primate Orbitofrontal Neurons

Emirhan Bugra Albayrak¹, Shira M. Lupkin, Vincent B. McGinty¹; ¹Rutgers University

Presenter: Emirhan Bugra Albayrak

The primate orbitofrontal cortex (OFC) plays a key role in economic decision-making by encoding economic value and other decision-related variables. It has been proposed that different subtypes of OFC neurons may have different encoding properties corresponding to different functions in decision-making. However, there has been no attempt to classify OFC neurons according to their physiological subtype in primates. Here, we identified putative neuron types using an unsupervised clustering algorithm based on the extracellular waveform. We found that specific clusters of neurons had distinct encoding profiles defined by the timing and magnitude of task variable representations. We also identified a cluster of putative pyramidal neurons with choice-predictive activity far above that of other subtypes. These results represent a first step in understanding the cell subtype-specific roles of OFC neurons in choice.

Topic Area: Reward, Value & Social Decision Making

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